In the current study, IBS-D patients that met the anxiety-depression criteria were selected according to the criteria of the anxiety-depression scales and then compared with the normal control and non-anxiety-depression IBS patients to determine differences in the levels of IL-1β and IL-10 in the blood and sigmoid mucous membranes, as well as mucosal positive cell expression. The gene discussed is IL1B; the disease is irritable bowel syndrome.