However, the levels of IL-10 in the blood and sigmoid colon mucosa in the anxiety-depression IBS-D group (27.36±8.24 and 24.31±5.66, respectively) were significantly lower than those in the non-anxiety-depression IBS-D group (30.34±7.33 and 28.45±3.34, respectively; P<0.05). The gene discussed is IL10; the disease is major depressive disorder.