A recently updated systematic review of randomized controlled trials (RCTs) of TCM formulations against HBV in China (from 1998 to 2008) suggests that TCMs have a similar antiviral activity as IFN/LAM (Lamivudine) on chronic hepatitis B, which was evidenced by the loss of serum HBeAg and HBV DNA [23]. The gene discussed is IFNA1; the disease is chronic hepatitis B virus infection.