This review summarizes recent research done on alternative targeted therapies with a particular focus on some important signaling pathways (such as Alox5, Hedgehog, Wnt/b-catenin, autophagy, and PML) that have the potential to target CML stem cells and potentially provide cure for CML. The gene discussed is ALOX5; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.