BCR-ABL independent activation of signaling such as Src/Ras/Raf/MEK/Lyn, STAT, Wnt/beta catenin, Hedgehog, FoxO, and SIRT1 may also play a role in resistance and CML progression [33]. Here, SIRT1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.