We believe, however, that further detailed study of PLAC1 in endometrial cancers is warranted and will ultimately lead to elucidation of the role of PLAC1 in uterine carcinogenesis, the mechanism determining PLAC1 transcription initiation, the role of estrogen in PLAC1 transcription, and development of PLAC1 as a biomarker of endometrial carcinogenesis and prognosis. Here, PLAC1 is linked to endometrial cancer.