In a study comparing normal reduction mammoplasty specimens to archival breast cancer specimens, Rogers et al. [7] found that CALML3 was expressed at high levels in normal breast epithelium and that significant CALML3 downregulation occurred in 79% to 88% of invasive ductal carcinoma and lobular carcinoma specimens. The gene discussed is CALML3; the disease is invasive ductal breast carcinoma.