This paper is accompanied by clinical study of Caserta et al. “Correlation of endocrine disrupting chemicals serum levels and white blood cells gene expression of nuclear receptors in a population of infertile women” compares the internal exposure to bisphenol A (BPA), perfluorooctane sulphonate (PFOS), perfluorooctanoic acid (PFOA), monoethylhexyl phthalate (MEHP), and di(2-ethylhexyl) phthalate (DEHP) in serum samples of 111 infertile women and 44 fertile women and analyses levels of gene expression of nuclear receptors (ERα, ERβ, AR, AhR, PXR, and PPARγ) as biomarkers of effective dose. This evidence concerns the gene ESR1 and Infertility.