We found an interaction between TF C2 and APOEε4 alleles (Table 3), evidence already described by some authors (Namekata et al., 1997) but not confirmed by others (Marklova et al., 2012) We observed that in AD patients with at least one copy of the APOEε4 allele, the frequency of the CT or TT genotype of TF C2 was almost twice as that in the remaining AD non-APOEε4 allele carriers. This evidence concerns the gene TF and Alzheimer disease.