NLGN3 and autism: In addition, mice lacking the neuroligin-3 gene (Nlgn3−/− mice), another autism model with an Nlgn3 deletion identified in autistic patients, show occluded metabotropic glutamatergic receptor (mGluR)-dependent long-term depression (LTD) at synapses between parallel fibers and Purkinje cells in association with motor coordination deficits (see also Table 5 for summary of synaptopathy ASD models) (Baudouin et al., 2012).