APC and adenoma: To address the mechanism underlying the reduction of adenoma formation in ApcMin/+Cited1− mice, we crossed Cited1− mice with mice conditionally mutant for Apc. We have previously demonstrated that we can achieve almost 100% recombination of the Apcfl/fl allele in the intestine using the β-napthoflavone inducible AhCre transgene to drive recombination [3].