In the present report we show that intracellular stability of pro-IL-1β is impaired by a post-translational control mechanism in HPV16-immortalized human keratinocytes (Fig. 4), therefore limiting their capacity to release mature IL-1β upon infection with adenovirus (Fig. 1A) or after treatment with Nigericine (Fig. 4G) which activates the NALP3 inflammasome. This evidence concerns the gene NLRP3 and infection.