TF and infection: Figure 6A depicts that the TF content in the plasma samples was not significant raised 10 hours after infection, but was significantly increased at the later time points (Figure 6A). Similar results were seen when measuring the concentrations of pro-coagulant MVs, though they already start to peak 10 hours after infection (Figure 6B). Thus, the data show that the generation of pro-coagulant MVs is part of the host response to invasive infection with S. pyogenes.