IL-1β, IL-6 and the chemokines CXCL1, CXCL11 and CXCL10 as well as IFNλ2/3 in the BAL peaked at day 2 after infection in HRV16 infected tg+ mice and those pre-treated with isotype control, whereas tg− littermates and 14C11 treated HRV16 infected tg+ mice failed to induce cytokine and chemokine production. The gene discussed is TG; the disease is infection.