To investigate the human ICAM-1-specificity of the action of 14C11 in vivo and to exclude possible interactions of the Fc part of the 14C11 antibodies we tested for possible inhibition by 14C11 in minor group HRV infection, which does not use human ICAM-1 as virus entry receptor and in an LPS challenge model where induction of airway inflammation is independent of human ICAM-1 (Figure 5 and Figure S3). Here, ICAM1 is linked to inflammatory response.