ICAM1 and infection: To test the effect of the anti-ICAM-1 antibody 14C11 in an in vivo major group HRV infection model, we challenged transgenic Balb/c mice over-expressing extracellular domain 1 and 2 of human ICAM-1 (tg+) and non-transgenic littermates (tg−) with major group HRV16 as described previously [24].