Compared to mice challenged with UV-inactivated HRV16 and OVA (UV-OVA), HRV16 and OVA challenge in isotype pre-treated tg+ mice (RV-OVA iso) significantly increased total BAL cell and neutrophil numbers on day 2 after infection, lymphocyte numbers on day 6 and increased airway hyper-responsiveness as measured by PenH at 24 hrs post-challenge. Here, TG is linked to infection.