MLXIPL and cytomegalovirus infection: In the case of HCMV infection SREBP1 cleavage may be insufficient to substantially activate lipogenesis in the absence of ChREBP induction, even though preventing SREBP1 cleavage using an shRNA specific for the enzyme SCAP (SREBP-cleavage activating protein) inhibited lipid synthesis and HCMV growth [10], [11].