Upon infection HCMV directly induces the interferon (IFN)-inducible iron-sulfur (Fe-S) cluster-binding protein, viperin [21], [22], [23], and we recently showed that the HCMV-encoded vMIA protein binds viperin and translocates it to mitochondria where it inhibits fatty acid β-oxidation [24]. Here, RSAD2 is linked to infection.