IFNA1 and infection: Conversely, while mDC from SIV naïve animals are largely incapable of producing IFN-α upon stimulation with SIV or virus-encoded oligonucleotides [43], we found that mDC taken after infection gained a modest capacity to produce IFN-α upon virus stimulation and also contributed to in situ-IFN-α production in acutely infected lymph nodes.