VAV3 and in situ carcinoma: By contrast, we observed that Vav2−/−;Vav3−/− FVB mice displayed lower kinetics of tumor development (Figure 1A), a ≈5-fold reduction in the total number of tumors developed per mouse (Figure 1B,C), and 10-fold lower levels of carcinoma in situ (Table S1) when subjected to the two-step DMBA/TPA carcinogenic method.