Vav2−/−;Vav3−/− FVB mice also displayed lower kinetics of tumor development (Figure 1G), a 2-fold reduction in tumor burden per mouse (Figure 1H,I), and a decrease in the percentage of cSCC development (Table S2) when subjected to the complete DMBA/DMBA tumorigenic method. This evidence concerns the gene VAV3 and neoplasm.