TLR2 and cerebral infarction: For example, in our recent studies it was demonstrated that the systemic administration of curcumin, oxymatrine, and luteolin during cerebral infarction, which have been proved to be anti-inflammatory agents, could improve neurological deficit, alleviate brain edema and infarct sizes, and regulate cytokines expression in cortex, such as downregulating p38MAPK, NF-κB, Toll-like receptor-2,4,5, and myeloid differentiation factor 88 [7, 30, 31].