Because IER3 is a modulator of apoptosis through TNFalpha or FAS-signaling (47), the balance between its repression (through MYC, E2F2 and E2F5 that are EWS-FLI1 induced and therefore disease specific) and activation (through NFkB) may be of particular interest in Ewing sarcoma. The gene discussed is E2F5; the disease is Ewing sarcoma.