The flow chart of our approach is illustrated in Figure 1A, and the causal relations between data and the influence network is represented in Figure 1B. The principle was to combine transcriptome time series obtained in vitro with literature data mining to construct a first version of the influence network dedicated to Ewing sarcoma focused on regulation of apoptosis and proliferation by EWS-FLI1. Here, FLI1 is linked to Ewing sarcoma.