Importantly, line 1566 does not contain Cd30 and Tnfr2. Consistent with our previously published finding (Yamanouchi et al. 2009) and shown here in three independent, previously unpublished, diabetes frequency studies (Fig. 2a, f, g), line 1566 was significantly protected from diabetes compared with NOD mice (P = 1 × 10−10, P = 3 × 10−10, and P = 3 × 10−6), demonstrating that this region retains Idd9.2. Here, TNFRSF8 is linked to diabetes mellitus.