Mutations in GATA4 cause human CHD, often in the form of septal defects, but other defects have been reported [89, 91, 196] Mice homozygous for targeted deletion of Gata4 display early defects in cardiogenesis [93, 94], and phenotypic characterization of mice homozygous for a hypomorphic allele of Gata4 supports that haploinsufficiency of GATA4 can cause CHD [95]. Here, GATA4 is linked to coronary artery disorder.