ZFYVE1 and cancer: To understand the link between Myc-modulated autophagy and cancer, we tested whether the compromise of autophagy resulting from Myc inhibition was mediated through changes in Bcl2, since the unphosphorylated form of this protein inhibits Beclin 1 to decrease the production of PI3P, which would manifest in decreased DFCP1 vesicles that was observed earlier (Fig. 1F).