Menin, by serving as a molecular adaptor, physically links the MLL histone methyl transferase with the lens epithelium-derived growth factor (LEDGF), which is a chromatin-associated protein implicated in the eitology of leukemia, autoimmunity and human immuno-defeciency virus-1 (HIV-1) disease (Roudaia and Speck, 2008; Yokoyama and Cleary, 2008). Here, PSIP1 is linked to Autoimmunity.