MEN1 and neoplasm: Firstly, in the context of familial MEN1 (Fig. 1), in which a patient with one MEN1-associated tumor, e.g. a prolactinoma, did not have the familial mutation; and secondly, in the context of clinical MEN1, in which patients with two MEN1-associated tumors, who did not have an MEN1 mutation, were demonstrated to have involvement of other genes.