MEN1 mutational analysis is helpful in clinical practice in several ways that include: (1) confirmation of the clinical diagnosis; (2) identification of family members who harbor the MEN1 mutation and require screening for tumor detection and early treatment; and (3) identification of the 50% of family members who do not habour the familial germline MEN1 mutation and can therefore be reassured and alleviated of the burden of anxiety of developing tumors. Here, MEN1 is linked to neoplasm.