MEN1 and Anxiety: MEN1 mutational analysis is helpful in clinical practice in several ways that include: (1) confirmation of the clinical diagnosis; (2) identification of family members who harbor the MEN1 mutation and require screening for tumor detection and early treatment; and (3) identification of the 50% of family members who do not habour the familial germline MEN1 mutation and can therefore be reassured and alleviated of the burden of anxiety of developing tumors.