Biomarker phenotypes can be grouped into four tumor categories with different histological characteristics: Luminal-A is ER+ and/or PR+/HER-2−, Luminal-B is ER+ and/or PR+/HER-2+, HER-2 overexpressed is ER−/PR−/HER-2+, and triple-negative (TN) is ER−/PR−/HER-2− [10, 12]. This evidence concerns the gene ERBB2 and neoplasm.