Meanwhile, among women with regional/distant staging, those with TN BC (HR: 5.48, 95% CI: 2.63–11.47) and HER-2+ (HR: 2.73, 95% CI = 1.30–5.75) had increased risk of death as compared to those with Luminal-A disease (Fig. 1A and B). The gene discussed is ERBB2; the disease is breast cancer.