TH and neuroblastoma: Recently, Teitz et al. reported that TH-NMYC transgenic mice, in which N-myc expression is driven by the rat tyrosine hydroxylase promoter, are a useful preclinical model of NB; however, these transgenic mice developed tumors in the paraspinal ganglia rather than in the adrenal glands [11], whereas approximately 40% of patient tumors originate in the adrenal medulla [1].