Contrariwise, patients homozygous for the p.Ala428Thr mutation [Ghezzi et al., 2012] or heterozygous with the less severe p.Arg477His mutation (Pt1 in this report), have milder symptoms, and are alive and relatively well at 20 and 14 years of age respectively, although both with compensated hypertrophic cardiomyopathy. This evidence concerns the gene ZNF77 and hypertrophic cardiomyopathy.