FLT3 and acute myeloid leukemia: Activating mutations in fms-like tyrosine kinase-3 (FLT3) represent one of the more frequent genetic alterations in AML (Rockova et al, 2011), involving internal tandem duplication (ITD) in the juxtamembrane (JM) domain of FLT3 (Nakao et al, 1996).