The rapid intraoperative determination of intact parathyroid hormone has become widely established in primary hyperparathyroidism surgical treatment, in which the removal of all hyperfunctioning parathyroid tissue is confirmed by a prompt decline in circulating iPTH within 5 to 10 minutes4, 12, 13, 16, 17, 18, 19. This evidence concerns the gene PTH and primary hyperparathyroidism.