This finding is in agreement with previous reports where SFN inhibited the in vitro migration of oral carcinoma cells by down regulation of MMP-1 and MMP-2 secretion and ovarian cancer cells by increasing apoptotic cell death via an increase in Bak/Bcl-2 ratio and cleavage of procaspase-9 and poly (ADP-ribose)-polymerase (PARP) [57,58]. This evidence concerns the gene BCL2 and lip and oral cavity carcinoma.