As shown Figure 1, c-Met (Figure 1D-1F), CA9 (Figure 1G and 1H) and GLUT1 (Figure 1I) expression was observed in the tumor cell membrane, while HIF-1α expression (Figure 1A-1C) was mainly observed in the cytoplasm, with some cases also demonstrating weak nucleus staining. This evidence concerns the gene HIF1A and neoplasm.