In CIN and CIS specimens, HIF-1α expression showed significant correlation with GLUT1 (Chi-square test; P = 0.001, Spearman’s rho = 0.217, P = 0.005) whereas HIF-1α expression was not correlated with those of CA9 (Chi-square test; P = 0.043, Spearman’s rho = 0.097, P = 0.195) and c-Met (Chi-square test; P = 0.136, Spearman’s rho = 0.137, P = 0.062) (data not shown). Here, HIF1A is linked to in situ carcinoma.