Furthermore, serum ANGPTL4 levels in most ESCC patients were decreased after 7–10 days of surgery, and the pre-/post-operative concentrations were 202.44 ± 131.03 ng/mL and 128.73 ± 69.49 ng/mL, respectively (P = 0.004). Here, ANGPTL4 is linked to esophageal squamous cell carcinoma.