ANGPTL4 and esophageal squamous cell carcinoma: In concordance with the results of Shibata et al. [10], we found that the level of ANGPTL4 protein expression in ESCC was much higher than that in matched normal tissues, and an elevated expression of ANGPTL4 protein was significantly associated with lymph metastasis, clinical stage, and adverse 2-year PFS, further confirming the important roles of ANGPTL4 dysfunction in ESCC development in Chinese population.