It must be pointed out that these two previous studies had reached contradictory conclusions, as in Nakazumi's study the difference in the percentage of stained nuclei between the ACA and ACC samples favored the marking of the benign tumors, and although statistically significant, this difference was less pronounced than the one observed in the more recent study carried out by Stojadinovic, which found increased p27 staining in malignant tumors, similar to that observed in our study (13, 25). The gene discussed is CDKN1B; the disease is adrenal cortex carcinoma.