However, a recent study showed that transfection of TRβ1 into human SK-hep1 cells reduced HCC xenograft tumor growth in nude mice, promoted partial mesenchymal-to-epithelial transition, attenuated tumor cell invasiveness, and blocked tumor cell responses to growth factors EGF, IGF-1, and TGF-β [86]. This evidence concerns the gene TGFB1 and neoplasm.