INS and diabetes mellitus: Of note is the lack of a significant increase in the HDL-cholesterol levels of the sulphonylurea group, which can be clinically favorable, since DM patients on sulphonylureas had a lower HDL-cholesterol than DMT2 patients on insulin and diet, not to mention the lower ability of sulphonylureas to improve the lipid profile, making it a positive risk factor for ischemic heart disease in patients with DMT2 [20-23].