In the study by Lim et al. [18] it was shown that 50 N-terminal amino acids of RPS3A are essential to interact with and to increase the solubility of the HBx (hepatitis B protein X) in hepatocellular carcinoma cells, whereas from the C-terminus up to 101 amino acids could be deleted without affecting this chaperone function. Here, RPS3A is linked to hepatocellular carcinoma.