USH2A and Usher syndrome: In our previous Sanger sequencing effort of nine Usher syndrome genes in 121 USH2 families, we identified two pathogenic/UV4/UV3 variants in 65% (79/121) of families, one pathogenic/UV4/UV3 variant in 21% (26/121) of families and no pathogenic/UV4/UV3 variants in 13% (16/121) of families.