A growing literature has demonstrated that the formation of a multi-protein NLRP3 inflammasome signaling complex and subsequent cytokine activation is an underlying mechanism of VAT (Vandanmagsar et al., 2011) and pancreatic (Schroder et al., 2010; Wen et al., 2012) inflammation contributing to metabolic dysfunction and diabetes. Here, NLRP3 is linked to diabetes mellitus.