IL1B and Hyperglycemia: Similarly, NLRP3 inflammasome activation in pancreatic β-cells is triggered by hyperglycemia, and subsequent IL-1β production contributes to β-cell death, suggesting the NLRP3 inflammasome as a sensor of chronically elevated glucose and a mediator of pancreatic dysfunction (Dinarello et al., 2010; Strowig et al., 2012).