NLRP3 and obesity due to melanocortin 4 receptor deficiency: Previous evidence demonstrates that both VAT (visceral adipose tissue) and pancreatic inflammation mediated by macrophage and T-cell activation of the NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome is principal in the induction of obesity, insulin resistance, and impaired glucose metabolism (Vandanmagsar et al., 2011; Wen et al., 2011; Goossens et al., 2012).