For instance, ACs and CRP-family proteins are required for full virulence in mouse infection models with the pathogens Mycobacterium tuberculosis, Pseudomonas aeruginosa, Salmonella typhimurium, and Yersinia enterocolitica[7]–[10]; in Vibrio cholerae, CRP is essential for in vivo colonization [11]. Here, CRP is linked to infection.