In agreement with clinical findings, where higher GPx activity has been inversely associated with cardiovascular events (both stroke and coronary artery disease) [24]–[28], the present study found higher GPx-3 activity to be cardio-protective, being related to younger age, normotensive status, lower BMI, higher HDL-cholesterol, lower triglycerides, and better renal function. This evidence concerns the gene GPX3 and Stroke.