Recently, the Systemic Lupus International Collaborating Clinics (SLICC) group has revised and validated the American College of Rheumatology SLE criteria where seventeen criteria were proposed, including clinical criterion and immunologic criterion (i.e malar rash, oral ulcers, serositis, positive anti-nuclear antigen ANA, anti-dsDNA, etc.)be identified during any interval of observation [52]. The gene discussed is BTG3; the disease is systemic lupus erythematosus.