Previous histone peptide microarray on streptavidin-glass slide identified several peptides capable of differentiating SLE patient sera and healthy patient sera, including unmodified histone H3 and H2B peptide and H2B peptide with the 5th, 12th, 15th, 20th lysine acetylated, [45] which was consistent with our data on glass (data not shown). This evidence concerns the gene H2BC21 and systemic lupus erythematosus.