FMO5 and cardiomyopathy: Moreover, Zn2+ elevates ROS, in living cells by inhibiting mitochondria [58] and activating NADPH oxidase [59] although it has been shown in an early study that oxidative phosphorylation rate and Mg2+-dependent ATPase activities were depressed in mitochondria from left ventricle of diabetic rat heart contributing into development of cardiomyopathy at late stages of diabetes [60].