CDH1 and colorectal carcinoma: To explore the connection with the CRC survival, our analysis combined the outcomes of 14 studies comprising 2730 CRC patients, indicating that the relationship between reduced E-cadherin expression and worse prognosis of CRC was obviously (HR = 2.27, 95%CI: 1.63–3.17; Z = 4.83; P = 0.000).