CDH1 and colorectal carcinoma: The pooled OR was 0.49(95% CI: 0.32–0.74, Z = 3.35, P = 0.001) and 0.45(95% CI: 0.22–0.91, Z = 2.24, P = 0.025) (Figure3C and 3D) (Table4), which suggested that downregulated E-cadherin expression was associated with metastasis of CRC.