CDH1 and colorectal carcinoma: The pooled OR was 0.36(95% CI: 0.19–0.7, Z = 3.03, P = 0.002) with heterogeneity (I2 67.4% P = 0.000) (Figure3A) (Table4), and it suggested that downregulated E-cadherin expression was associated with differentiation of CRC.