Furthermore, the ability of SAHA to induce ABCD2 gene expression in hippocampal slice cultures from epilepsy patients (Fig. 10) suggests that increased β-oxidation activities and lowering of ELOVLs by SAHA can mediate the overall effect of lowering of VLCFA levels in X-ALD patients, especially in neural cells. The gene discussed is ABCD2; the disease is epilepsy.