ABCD2 and X-linked adrenoleukodystrophy: In agreement with our recent observation in human X-ALD fibroblasts [35], SAHA upregulated Abcd2 gene expression and VLCFA β-oxidation activity in Abcd1-deficient human U87 astrocytes and rat B12 oligodendroglia, and lowered the levels of C26∶0 and C26∶1 in Abcd1-deficient U87 astrocytes in the present study.