Although no significant difference in the levels of ELOVL1 and ELOVL3 in control and X-ALD fibroblasts was observed [18], [35], indicating that availability of substrate is the limiting factor for their elongation, increased expression of ELOVL3 has been reported to be linked to accumulation of VLCFA [20]. This evidence concerns the gene ELOVL3 and X-linked adrenoleukodystrophy.