In agreement with our previous study using cultured X-ALD skin fibroblasts [35] SAHA treatment (5 μM) also reduced the accumulation (P<0.002) of C26∶1 in Abcd1-deficient U87 astrocytes and B12 oligodendrocytes (Fig. 4B and D). The gene discussed is ABCD1; the disease is X-linked adrenoleukodystrophy.