ABCD1 and X-linked adrenoleukodystrophy: Indeed, silencing of Abcd2 in addition to Abcd1 causes a greater accumulation of VLCFA that triggered a neuroinflammatory response associated with demyelination in X-ALD [7] and with a more severe axonal degeneration in Abcd1 null mice [34], and overexpression of Abcd2 prevented the accumulation of VLCFA [34], [76] and ameliorated the neurological signs of disease in Abcd1-KO mice [34].