In a multivariate model, histology (large cell carcinoma, HR 2.2, 95% CI., 1.4–3.4, p<0.01), spinal bone metastasis (HR 1.7, 95% CI., 1.2–2.6, p<0.01), and mutational status (EGFR mutation, HR 0.3, 95% CI., 0.1–0.6 p<0.01) were significantly associated with survival. The gene discussed is EGFR; the disease is large cell carcinoma.