In this study, we investigated the role of Fas receptor in HSV-2 infected monocytes using a monocyte cell line and a well-established murine model of genital herpes in MRL-Fas(lpr)/J (Fas−/−), C3-Fasl(gld)/J (FasL−/−) and C57BL6 mice. This evidence concerns the gene FASLG and genital herpes.