The present meta-analyses of T1D focus on four immunomodulatory genes including IL2RA, NLRP1, IL12B and CLEC16A. IL2RA gene encodes the α-chain of IL-2 receptor (IL-2R) complex which acts as an important modulator to regulate T-cell immune response [13]. Here, NLRP1 is linked to type 1 diabetes mellitus.