In the brain, HO-1 has been shown to be cytoprotective in models of stroke, excitotoxicity, Parkinson’s disease, and Alzheimer’s disease while NQO1 has been shown to be protective against a model of Parkinson’s disease [63], [64], [65], [66], [67], [68]. Here, NQO1 is linked to early-onset autosomal dominant Alzheimer disease.