To investigate whether E- and P-selectin mediate tethering or adherence of human CEL and CML cells under shear stress (more closely reflecting in vivo conditions than the static incubation in the flow cytometry experiments), laminar flow adhesion experiments with both cells lines, EOL-1 and K562, were performed. The gene discussed is SELP; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.