In multivariate regression analysis among CAD patients, the independent determinants of annual eGFR decline rate were age (r = –0.20, P<0.01), serum levels of albumin (r = 0.16, P = 0.02) and hs-CRP (r = –0.14, P = 0.04), and plasma levels of MMP-2 (r = –0.22, P<0.01), MMP-3 (r = –0.19, P = 0.01), and MMP-9 (r = –0.29, P<0.01). The gene discussed is MMP9; the disease is coronary artery disorder.