Third, although it reported that the regulation of the glucose stimulated insulin secretion and mTORC1 and ERK1/2 signal pathway are involved in Nampt-media NAD salvage synthesis [12], [44], other signaling pathways involving Nampt, such as PI3K/Akt [45] and STAT3 [46], [47], also participate in tumor formation, transformation, and angiogenesis. This evidence concerns the gene MAPK3 and neoplasm.