SORT1 and neuroblastoma: Consistent with previous reports [20], [21], downregulation of mTdp-43 in mouse N2a neuroblastoma cells by small inference RNA (siRNA) significantly increased the levels of the abnormal splicing variants: mSort1+Ex17b (sortilin 1 including exon 17b) and mTsn_ΔEx5 (translin with exon 5 deletion) (siTardbp, Fig. 2A).