Thus, HPV-positive oropharyngeal tumors are associated with oral sex, under 60 years of age, infrequent p53 gene mutation, and a more favorable clinical outcome, while HPV-negative carcinoma is associated with smoking, excessive alcohol use, above 60 years of age, frequent p53 gene mutation, and poor prognosis [4]. Here, TP53 is linked to neoplasm of oropharynx.